With the rise in cancer‚ especially among younger populations‚ Johnson &; Johnson appears set on profiting from this market. The pharmaceutical giant paid $2 billion in cash to acquire Ambrx Biopharma‚ a company specializing in cancer treatment. Johnson &; Johnson's Acquisition Of Ambrx Biopharma: Hold Through It https://t.co/gdzZu7DADA pic.twitter.com/fn3wbRdRFw — Jake P. Noch (@Jake_P_Noch) January 11‚ 2024 “Johnson &; Johnson announced today it has entered into a definitive agreement to acquire Ambrx Biopharma‚ Inc.‚ or Ambrx‚ a clinical-stage biopharmaceutical company with a proprietary synthetic biology technology platform to design and develop next-generation antibody drug conjugates (ADCs)‚ in an all-cash merger transaction for a total equity value of approximately $2.0 billion‚ or $1.9 billion net of estimated cash acquired‚” the company announced. From Johnson &; Johnson: Ambrx is advancing a focused portfolio of clinical and preclinical programs designed to optimize efficacy and safety of its candidate therapeutics in multiple cancer indications‚ including ARX517‚ its proprietary ADC targeting PSMA for metastatic castration-resistant prostate cancer (mCRPC); ARX788‚ its proprietary ADC targeting human epidermal growth factor receptor 2 (HER2) for metastatic HER2+ breast cancer; and ARX305‚ its proprietary ADC targeting CD-70 for renal cell carcinoma. “Ambrx’s ADC technology offers unique advantages in the conjugation of stable antibodies and cytotoxic linker payloads‚ which results in engineered ADCs that effectively kill cancer cells and limit toxicities‚” said Yusri Elsayed‚ M.D.‚ M.H.Sc.‚ Ph.D.‚ Global Therapeutic Area Head‚ Oncology‚ Johnson &; Johnson Innovative Medicine. “The results seen to date with ARX517 in mCRPC are promising and represent a potential first- and best-in-class targeted therapy for the treatment of this aggressive disease. In addition‚ Ambrx’s pipeline and ADC platform present exciting future opportunities to deliver enhanced‚ precision biologics as we look to transform the treatment of cancer and improve patients’ lives.” The planned acquisition presents a distinct opportunity for Johnson &; Johnson to design‚ develop and commercialize targeted oncology therapeutics. Ambrx’s proprietary ADC technology incorporates the advantages of highly specific targeting monoclonal antibodies securely linked to a potent chemotherapeutic payload to achieve targeted and efficient elimination of cancer cells without the prevalent side-effects typically associated with chemotherapy. Building on a legacy of innovation in oncology and in prostate cancer‚ J&;J scientists intend to work with Ambrx researchers‚ accelerating the Phase 1/2 APEX-01 study (NCT04662580) of ARX517 in advanced prostate cancer‚ while progressing a pipeline of novel ADC product candidates. “We are excited to reach this agreement with Johnson &; Johnson for advancing scientific research to treat cancers with high unmet needs‚” said Daniel J. O’Connor‚ Chief Executive Officer of Ambrx. “With our deep and unique knowledge of precision engineering of protein therapeutics enabled by our proprietary technology incorporating synthetic amino acids in living cells‚ Ambrx has developed next generation novel drug candidates such as site-specifically conjugated highly stable antibody drug conjugates. Through this transaction‚ we will continue to advance our leading prostate cancer candidate and Ambrx’s promising pipeline‚ while delivering significant and certain cash value to our shareholders. This announcement is the culmination of two decades of scientific work‚ combined with the Ambrx team’s talent‚ hard work and innovation. I look forward to what Ambrx will achieve as part of Johnson &; Johnson‚” he added. CNBC reports: Ambrx is aiming to target multiple cancers with drugs called antibody-drug conjugates‚ or ADCs‚ which are described by researchers as “guided missiles” to directly target and kill cancer cells and minimize damage to healthy tissue. The deal‚ which was announced on the first day of the annual JPMorgan Healthcare Conference‚ makes J&;J the latest drugmaker to bet on ADCs following similar moves by other large rivals – including Pfizer‚ AbbVie and Merck – over the last year. The acquisition also comes as J&;J scrambles to fill a revenue hole that’s approaching in 2025‚ when its top-selling drug Stelara‚ which is used to treat a long-lasting autoimmune disease called psoriasis‚ is expected to face generic competition. “Johnson &; Johnson to acquire $2 billion drug developer ‘Ambrx Biopharma’ to treat Turbo Cancers with same tech as Pfizer’s $43 billion Seagen acquisition. Both set their sights on 2025 Cancer TSUNAMI‚” Dr. William Makis writes. “Pfizer &; Moderna COVID-19 mRNA Vaccines cause Turbo Cancers‚ this is now well acknowledged by respected physicians around the world. Last month‚ Pfizer closed a $43 billion acquisition of Seagen‚ to boost its ability to treat 7 of the top 10 Turbo Cancers caused by its COVID-19 mRNA Vaccine‚” he added. NEW ARTICLE: Johnson &; Johnson to acquire $2 billion drug developer "Ambrx Biopharma" to treat Turbo Cancers with same tech as Pfizer's $43 billion Seagen acquisition. Both set their sights on 2025 Cancer TSUNAMI Pfizer &; Moderna COVID-19 mRNA Vaccines cause Turbo Cancers‚ this… pic.twitter.com/Ehl9UvXl8s — William Makis MD (@MakisMD) January 17‚ 2024 Makis writes: Top 5 Turbo Cancers: lymphoma‚ glioblastoma‚ breast‚ colon‚ lung Top 10 Turbo Cancers: leukemia‚ melanoma‚ sarcomas‚ testicular/ovarian‚ kidney Pfizer expects a “Cancer Tsunami” to hit in 2025 Moderna is rushing its melanoma mRNA Cancer vaccine to have expedited approval by 2025. Johnson &; Johnson is the latest to want a piece of the Turbo Cancer treatment pie before 2025. This $2 billion acquisition of Ambrx Biopharma gives them the same cancer treatment tech as Pfizer – ADCs. ADC: “a class of therapeutics that combines the specificity of monoclonal antibodies with the potency of cytotoxic drugs‚ aiming to target and destroy cancer cells more effectively” Johnson &; Johnson‚ for $2 billion‚ adds new ability to treat Breast Turbo Cancer‚ Prostate Turbo Cancer and Kidney Turbo Cancer with this acquisition. They also overpaid by more than 100% of the current Ambrx Biopharma stock price. Acquisition expected to close in mid 2024. Many pharmaceutical companies are rushing to position themselves to profit from treating a tsunami of cancers that they are all expecting to hit starting in 2025. Dec.14‚ 2023 – Pfizer closed a $43 billion acquisition to treat several turbo cancers and expects to “fill a gap” for the period 2025-2030. Dec.14‚ 2023 – Moderna targets new mRNA Cancer vaccine to treat melanoma to be available by 2025 Jan.8‚ 2024 – Johnson &; Johnson to acquire $2 billion cancer drug company that uses same tech as Pfizer‚ to “fill a revenue gap starting in 2025” Jan.10‚ 2024 – BioNTech expects to return to revenue growth in 2025‚ when its COVID vaccine business would bottom out‚ and it would invest to “scale up its oncology business thereafter” Many companies that have new blood tests or light tests to quickly detect cancer are all targeting 2025 for their launch. I provide examples. Dozens of giant Cancer Centers are going up all across the US‚ Canada‚ Australia and UK – all of them are opening in 2025. They’re ready for the 2025 Cancer TSUNAMI. Are you? Read more about ‘Turbo Cancer‘: The Truth Behind “Turbo Cancer”

Mike Dickson‚ a legendary tennis correspondent‚ reportedly collapsed and died at the Australian Open. Dickson‚ 59‚ passed away on Wednesday. “Dickson was a hugely respected and admired journalist who spent 38 years in the industry – 33 at the Mail having started in 1990 – and his loss will be felt deeply by colleagues‚” Daily Mail reports. “He previously worked as the Mail’s cricket correspondent before moving over to tennis and covered 30 different sports across nearly 50 countries in total during a rich career‚” the outlet added. Novak Djokovic pays tribute to legendary Mail Sport tennis correspondent Mike Dickson as the sport mourns the loss of 'Mr Wimbledon'‚ who tragically died aged 59 covering the Australian Open https://t.co/Upnbq8sMli pic.twitter.com/eqmI09b6gi — Daily Mail Online (@MailOnline) January 18‚ 2024 Condolences to Mike Dickson family Rest in Peace https://t.co/skSMgwvBcZ — Novak Djokovic (@DjokerNole) January 18‚ 2024 Per Daily Mail: Dickson was in Melbourne covering the Australian Open when he died and a matter of days away from his 60th birthday‚ on January 27‚ with the news being announced by his family at around 11:30PM local time. Henman was visibly upset on Eurosport when paying tribute to Dickson. ‘It’s incredibly sad that he passed away in Melbourne‚’ he said‚ with his voice cracking. ‘He was a great friend of the tennis community and our thoughts go out to his family.’ Nadal meanwhile posted: ‘Very sorry to hear about the passing of Mike who has been following tennis all these years. My thoughts to his family and to our tennis family for the loss. Rest in peace.’ World No 4 Coco Gauff tweeted: ‘I am so sorry to hear this news. Sending my deepest condolences and may he rest in peace.’ Former World No 1 Tracy Austin added: ‘Heartbroken by this shocking news. Enjoyed working with Mike over the years. Sending condolences to his family.’ Three-time Wimbledon champion Boris Becker also paid tribute. ‘Terrible news out of Melbourne! My sincere condolences to the family of Mike Dickson‚ who passed away this morning…RIP Mike‚’ he wrote. Dickson’s esteemed work covering Wimbledon over the years saw him dubbed ‘Mr Wimbledon‚ and the tournament’s official X account said: ‘All of us at Wimbledon are deeply saddened to hear this news. Sports reporter aged 59 collapses and died while in Melbourne for the Australian Open.Impossible to state it was the jab‚ which he must have had to cover such events 2 years ago‚ but statistically I would say it is likely.#DiedSuddenly https://t.co/U6Ju2qZ97l — John Bull (@54JohnBull) January 17‚ 2024 The Telegraph added: He was due to turn 60 on January 27 but his death was confirmed in a social media post by his wife and children. “We are devastated to announce that our wonderful husband and Dad‚ Mike‚ has collapsed and died while in Melbourne for the Aus Open‚” said a message via Dickson’s page on X‚ formerly known as Twitter. “For 38 years he lived his dream covering sport all over the world. He was a truly great man and we will miss him terribly‚” added the message from “Lucy‚ Sam‚ Ruby and Joe”. Dickson‚ originally from the Wirral‚ lived with his family in Wimbledon. He had been a regular at major events in tennis‚ cricket‚ horse racing and golf for decades. He had contributed to a host of books too‚ including the Sunday Times bestseller Bob Willis: A Cricketer and a Gentleman. Among his many friends in sport was Michael Vaughan‚ the Ashes-winning England captain and Telegraph Sport columnist. Dickson had been enthusiastically covering the tennis in Melbourne this week‚ posting on Tuesday “many happy returns to Grand Slam action for Emma Raducanu” after she beat Shelby Rogers 6-3‚ 6-2 “with minimum of fuss”.

French prog rockers Lazuli tell the story of their eleventh studio album‚ cunningly titled 11

Jazz rocker explores modes‚ plaintive tones and mysticism on his album‚ featuring old bandmate Dave Bainbridge

A teen named Griffin awoke early in the morning as his dog nipped him repeatedly. However‚ the reason for the pup’s odd behavior soon became evident. And now‚ both Griffin and his mom can’t stop thanking their fur angel! Our pets are truly a blessing from God. Not only do they provide us with companionship and unconditional love‚ but our animals can even act as our furry protectors. RELATED: Danger Came Prowling But Family Dog Chased Off Burglar And Saved Special Needs Son There are countless stories of man’s best friend stepping in to save humans. And that’s exactly what happened on New Year’s Eve between a dog named Macho and his teenage brother‚ Griffin. Dog Nipped Sleeping Teen Single mom Nicole Evans was out of town when the incident occurred. Her teenage son‚ Griffin‚ was in his room sleeping at 5:30 am when Macho started behaving very strangely. The dog nipped at Griffin repeatedly‚ refusing to leave him alone. “He just kept going at him‚” Nicole described. “And then he just gave him a nip‚ a couple of them‚ and woke him up.” RELATED: Devoted Dog Pays The Ultimate Price And Saves His Beloved Human From A Fire The behavior was completely unusual for‚ Macho‚ who is typically very laid back. But Macho sensed a danger Griffin didn’t. And the devoted dog knew that what was happening was anything but typical. A fire had broken out inside the home‚ the cause of which is still under investigation. Griffin‚ sound asleep‚ had no idea until the dog nipped awake. And that’s when the teen realized the dog’s persistence wasn’t “aggression‚” but rather urgency as he knew waking his owner was a matter of life and death. Macho managed to wake Griffin to escape the raging house fire just in the nick of time. “As soon as he turned around‚ there was just no doubt he had to go. He had to go quickly‚” Nicole recalled. What Remains The fire completely destroyed Nicole Evans’ home. And finding out about the disaster while out of town was a nightmare for the single mom. “It was probably the worst experience of my life to not be with the person you love the most while something’s happening to them that you can’t do something about‚” Nicole explained. However‚ while she lost nearly everything she owns‚ it’s what survived the fire that’s most important to Nicole. “All those things are just things‚ and some of those things do matter. They do‚ but in the end‚ it’s all replaceable‚” she said. “He’s not replaceable‚ my dog is not replaceable‚ and I wouldn’t have wanted it to have resulted in anything other than this.” YOU MAY ALSO LIKE: Dog Keeps Breaking into Nursery and Mom Is Fed up Until She Realizes Her Baby's Not Breathing Meanwhile‚ Nicole won’t face this difficult time alone. From the moment news of the fire spread‚ support began pouring in for Nicole‚ Griffin‚ and Macho. Neighbors are helping the family get back on their feet and a GoFundMe account is allowing friends and strangers alike to provide support as well. God certainly blessed this family when He brought them Macho! WATCH: Dog Nipped Sleeping Teen And Saved Him From Fire  LISTEN: Bride's Father Has Embarrassing Moment Walking Down | Husband Went to the Store and Ended Up Winning Millions h/t: Sunny Skyz Featured Image Credit: Youtube/WFLA News Channel 8 The post Teen Is Shocked As Trusted Pet Dog Suddenly Nips Him in the Night‚ but Then He Smells Smoke appeared first on GodUpdates.